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lüll Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities Kristie TM; Liang Y; Vogel JLBiochim Biophys Acta 2010[Mar]; 1799 (3-4): 257-65The immediate early genes of the alpha-herpesviruses HSV and VZV are transcriptionally regulated by viral and cellular factors in a complex combinatorial manner. Despite this complexity and the apparent redundancy of activators, the expression of the viral IE genes is critically dependent upon the cellular transcriptional coactivator HCF-1. Although the role of HCF-1 had remained elusive, recent studies have demonstrated that the protein is a component of multiple chromatin modification complexes including the Set1/MLL1 histone H3K4 methyltransferases. Studies using model viral promoter-reporter systems as well as analyses of components recruited to the viral genome during the initiation of infection have elucidated the significance of HCF-1 chromatin modification complexes in contributing to the final state of modified histones assembled on the viral IE promoters. Strikingly, the absence of HCF-1 results in the accumulation of nucleosomes bearing repressive marks on the viral IE promoters and silencing of viral gene expression.|Alphaherpesvirinae/*physiology[MESH]|Chromatin/*metabolism[MESH]|DNA Methylation[MESH]|Gene Expression Regulation, Viral/*physiology[MESH]|Genes, Immediate-Early/*genetics[MESH]|Histones/metabolism[MESH]|Host Cell Factor C1/genetics/*metabolism[MESH]|Humans[MESH]|Transcription, Genetic[MESH] |