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FV100 as a new approach for the possible treatment of varicella-zoster virus infection McGuigan C; Balzarini JJ Antimicrob Chemother 2009[Oct]; 64 (4): 671-3FV100 is a promising new agent with extreme potency and specificity for varicella-zoster virus (VZV). It is the valyl ester pro-drug of Cf1743, the lead clinical candidate among the highly lipophilic bicyclic nucleoside analogue (BCNA) family discovered in Cardiff/Leuven. Cf1743 is unique amongst antivirals in terms of its structure and lipophilicity. It is exquisitely potent and selective for human VZV. FV100 has recently entered a randomized, controlled Phase II clinical trial for the treatment of shingles, sponsored by Inhibitex.|Antiviral Agents/*therapeutic use[MESH]|Controlled Clinical Trials as Topic[MESH]|Herpes Zoster/*drug therapy[MESH]|Herpesvirus 3, Human/*drug effects[MESH]|Humans[MESH]|Pyrimidine Nucleosides/*therapeutic use[MESH] |