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lüll Versatile somatic gene transfer for modeling neurodegenerative diseases Klein RL; Wang DB; King MANeurotox Res 2009[Oct]; 16 (3): 329-42A growing variety of technical approaches allow control over the expression of selected genes in living organisms. The ability to deliver functional exogenous genes involved in neurodegenerative diseases has opened pathological processes to experimental analysis and targeted therapeutic development in rodent and primate preclinical models. Biological adaptability, economic animal use, and reduced model development costs complement improved control over spatial and temporal gene expression compared with conventional transgenic models. A review of viral vector studies, typically adeno-associated virus or lentivirus, for expression of three proteins that are central to major neurodegenerative diseases, will illustrate how this approach has powered new advances and opportunities in CNS disease research.|*Gene Transfer Techniques[MESH]|Animals[MESH]|Disease Models, Animal[MESH]|Genetic Engineering/methods[MESH]|Genetic Therapy/*methods[MESH]|Genetic Vectors/physiology[MESH]|Humans[MESH]|Lentivirus/genetics[MESH]|Neurodegenerative Diseases/*genetics/*therapy[MESH] |