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Role and mechanism of U1-independent pre-mRNA splicing in the regulation of alternative splicing Fukumura K; Inoue KRNA Biol 2009[Sep]; 6 (4): 395-8In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent premRNA splicing occurs in humans, which contributes to the regulation of alternative splicing. So far it has been reported that several pre-mRNAs were spliced efficiently in a U1 snRNP-independent manner in vitro. Although the molecular mechanism and functional significance of U1-independent pre-mRNA splicing are not well understood, a model of how the 5' splice site is recognized U1-independently has been proposed. In this review, we first overview a model in which the 5' splice site is recognized by SR proteins and U6 snRNA. We then discuss our novel model and the functional significance of U1-independent pre-mRNA splicing in the regulation of alternative splicing, based on our recent work.|Alternative Splicing/*genetics[MESH]|Animals[MESH]|Eukaryota/genetics[MESH]|Humans[MESH]|Models, Biological[MESH]|RNA Precursors/*genetics[MESH]|Ribonucleoprotein, U1 Small Nuclear/*metabolism[MESH] |
