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lüll Is there more to Wnt signalling in breast cancer than stabilisation of beta-catenin?Collu GM; Meurette O; Brennan KBreast Cancer Res 2009[]; 11 (4): 105Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic beta-catenin and the subsequent changes in the expression of T-cell factor (TCF)-dependent genes. However, this is not necessarily the only mechanism, as Wnt proteins can signal through a number of different intracellular signalling pathways. The ongoing work from Nancy Hynes' laboratory continues to highlight this latter possibility.|*Signal Transduction[MESH]|Animals[MESH]|Breast Neoplasms/*physiopathology[MESH]|Cell Line, Tumor/transplantation[MESH]|ErbB Receptors/physiology[MESH]|Extracellular Signal-Regulated MAP Kinases/physiology[MESH]|Female[MESH]|Frizzled Receptors/physiology[MESH]|Humans[MESH]|Mice[MESH]|Neoplasm Proteins/*physiology[MESH]|Neoplasm Transplantation[MESH]|Wnt Proteins/*physiology[MESH]|beta Catenin/*physiology[MESH] |