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lüll More about masitinib Walker UAArthritis Res Ther 2009[]; 11 (4): 120A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 responses in 54%, 26% and 8% of patients, respectively. A placebo group was not included. Thirty-seven per cent of the patients withdrew before the 12-week end-point was reached, primarily because of adverse events. These findings are the first on the efficacy of tyrosine kinase inhibition in a sizeable population. Future work should focus on delineating the tyrosine kinase that is most important in maintaining rheumatoid activity and address potential long-term toxicities such as gonadal insufficiency, teratogenicity and cardiotoxicity.|*Clinical Trials, Phase II as Topic[MESH]|Antirheumatic Agents/*therapeutic use[MESH]|Arthritis, Rheumatoid/*drug therapy[MESH]|Benzamides[MESH]|Humans[MESH]|Piperidines[MESH]|Pyridines[MESH]|Thiazoles/therapeutic use[MESH] |