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lüll Uric acid: a novel mediator and marker of risk in chronic kidney disease?Feig DICurr Opin Nephrol Hypertens 2009[Nov]; 18 (6): 526-30PURPOSE OF REVIEW: To assess the current data suggesting that uric acid-lowering therapy may be useful in the prevention or mitigation of chronic kidney disease (CKD). RECENT FINDINGS: Eleven observational studies assessing the potential role of serum uric acid in the prevalence and progression of CKD have been published in the past 2 years. Seven suggest an association, whereas four do not. Recent experimental models and clinical trials have mechanistically linked serum uric acid and hypertension, an established risk factor for CKD. SUMMARY: Elevated serum uric acid is a marker for decreased renal function, may have a mechanistic role in the incidence and progression of renal functional decline and likely has a causal role in hypertension and vascular disease. Clinical trials are needed to determine whether uric acid-lowering therapy will be effective in preventing CKD.|Animals[MESH]|Biomarkers/blood[MESH]|Chronic Disease[MESH]|Clinical Trials as Topic[MESH]|Disease Models, Animal[MESH]|Disease Progression[MESH]|Evidence-Based Medicine[MESH]|Humans[MESH]|Hypertension/blood/etiology[MESH]|Hyperuricemia/blood/*complications/drug therapy/epidemiology[MESH]|Kidney Diseases/blood/epidemiology/*etiology/prevention & control[MESH]|Predictive Value of Tests[MESH]|Risk Assessment[MESH]|Risk Factors[MESH]|Treatment Outcome[MESH]|Up-Regulation[MESH]|Uric Acid/*blood[MESH] |