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lüll Understanding adenomyosis: a case control study Taran FA; Weaver AL; Coddington CC; Stewart EAFertil Steril 2010[Sep]; 94 (4): 1223-1228OBJECTIVE: To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas. DESIGN: Retrospective case-control study. SETTING: Academic medical center. PATIENT(S): The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis. INTERVENTION(S): Retrospective medical record review of hospital and ambulatory records. MAIN OUTCOME MEASURE(S): Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone. RESULT(S): Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing>150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas. CONCLUSION(S): Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.|Adult[MESH]|Algorithms[MESH]|Case-Control Studies[MESH]|Comprehension[MESH]|Endometriosis/diagnosis/*etiology/surgery[MESH]|Female[MESH]|Gynecologic Surgical Procedures[MESH]|Humans[MESH]|Leiomyoma/diagnosis/etiology/surgery[MESH]|Medical Records/statistics & numerical data[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|Risk Factors[MESH]|Uterine Diseases/diagnosis/*etiology/surgery[MESH]|Uterine Neoplasms/diagnosis/etiology/surgery[MESH] |