Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Pathophysiological role of autoantibodies against G-protein-coupled receptors in the cardiovascular system Schulze W; Kunze R; Wallukat GExp Clin Cardiol 2005[Fal]; 10 (3): 170-2After more than 15 years of intensive research in the field of functional autoantibodies (AAB) directed against G-protein-coupled receptors, there is growing evidence of a causal involvement of AAB in various cardiovascular diseases such as dilated cardiomyopathy, peripartum cardiomyopathy, malignant and essential hypertension, and preeclampsia. It has been indicated that AAB against beta-1 adrenergic receptor, alpha-1 adrenergic receptor, angiotensin-II receptor AT(1) and muscarinic M(2)-receptors undergo agonist-like actions on the corresponding receptor and induce a permanent stimulation of G-protein-coupled signal cascades, which may cause Ca(2+) overload and cardiomyocyte destruction.Furthermore, the present review describes how G-protein-coupled receptor AAB are able to activate transcription factor nuclear factor-kappa B, which may regulate the expression of genes involved in immune and inflammatory responses.ä |