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The evolution of platelet-directed pharmacotherapy Becker RC; Smyth SJ Thromb Haemost 2009[Jul]; 7 Suppl 1 (ä): 266-71The evolution of platelet directed pharmacotherapy in the prevention and treatment of patients with thrombotic disorders is based soundly on a rapidly expanding knowledge of platelet biology. Traditionally viewed, throughout most of its relatively brief history in medicine, as an anucleate, passive contributor to hemostasis, a more contemporary perspective acknowledges platelets as complex, multidimensional cells that participate actively in coagulation, vascular repair, angiogenesis and thrombosis within the micro and the macro-circulatory systems. Herein, we consider platelet-directed pharmacotherapy from these fundamental, biology-based exemplars--megakaryocytes, signal transduction and the platelet--coagulation protease interface. We also highlight the emerging biopharmacology platform of oligonucleotide platelet adhesion antagonists and their complementary antidotes.|Blood Platelets/*drug effects/metabolism[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Humans[MESH]|Megakaryocytes[MESH]|Oligonucleotides/pharmacology/therapeutic use[MESH]|Platelet Aggregation Inhibitors/history/pharmacology/therapeutic use[MESH]|Signal Transduction[MESH]|Thrombosis/*drug therapy/prevention & control[MESH] |
