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lüll Selective sorting of alpha-granule proteins Italiano JE Jr; Battinelli EMJ Thromb Haemost 2009[Jul]; 7 Suppl 1 (Suppl 1): 173-6One of the main functions of blood platelets is to secrete a variety of substances that can modify a developing thrombus, regulate the growth of the vasculature, promote wound repair, and contribute to cell-adhesive events. A majority of this vast array of secreted proteins are stored in alpha-granules. Until recently, it was assumed that platelets contained one homogeneous population of alpha-granules that undergo complete de-granulation during platelet activation. This review focuses on the mechanisms of alpha-granule biogenesis and secretion, with a particular emphasis on recent findings that clearly demonstrate that platelets contain distinct subpopulations of alpha-granules that undergo differential release during activation. We consider the implications of this new paradigm of platelet secretion, discuss mechanisms of alpha-granule biogenesis, and review the molecular basis of transport and delivery of alpha-granules to assembling platelets.|*Protein Transport[MESH]|Blood Platelets/*metabolism[MESH]|Humans[MESH]|Secretory Vesicles/*metabolism[MESH] |