suck pdf from google scholar
PDF vom PMID19630761 :   free
PDF vom PMID19630761
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lll
  • von Willebrand factor assembly and secretion
  • Sadler JE
  • J Thromb Haemost 2009[Jul]; 7 Suppl 1 (): 24-7
  • During its life history, von Willebrand factor (VWF) experiences a remarkable sequence of conformational changes that are triggered by differences in pH between the endoplasmic reticulum (ER), Golgi and extracellular environments. VWF subunits dimerize in the ER and assemble into disulfide-linked multimers in the trans-Golgi, which lacks known chaperones and has an acidic pH that inhibits disulfide rearrangement. VWF has circumvented these problems by evolving N-terminal domains that function as an oxidoreductase at the low pH of the Golgi. VWF multimers also condense into tightly packed, tubular arrays for storage in the Weibel-Palade bodies of endothelial cells. Like multimer assembly, tubular packing depends on low pH and Ca2+. Upon secretion, exposure to the neutral pH of the extracellular environment allows enormous VWF multimers to uncoil without tangling, which is crucial for hemostasis. Recent studies have identified some of the biochemical and structural properties that underlie these self-organizing behaviors.
  • |Disulfides[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Protein Conformation[MESH]
  • |Protein Multimerization[MESH]
  • |Protein Transport[MESH]
  • |von Willebrand Factor/chemistry/*metabolism[MESH]





  • *{{pmid19630761}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=19630761 von Willebrand factor assembly and secretion ]</b> J Thromb Haemost 2009; 7 Suppl 1() ; 24-7 Sadler JE

        *19630761*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    J Thromb Haemost

    24 .7 Suppl 1 2009