Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon Prestwich RJ; Errington F; Diaz RM; Pandha HS; Harrington KJ; Melcher AA; Vile RGHum Gene Ther 2009[Oct]; 20 (10): 1119-32The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy. Classically, the immune system is thought to limit the efficacy of therapy, leading to viral clearance. However, preclinical and clinical data suggest that in some cases virotherapy may in fact act as cancer immunotherapy. In this review we discuss the ability of oncolytic viruses to alter the immunogenic milieu of the tumor microenvironment, and the role of innate and adaptive immunity in both restricting and augmenting therapy. Strategies to improve virotherapy by immunomodulation, including suppression or enhancement of the innate and adaptive responses, are discussed.|*Oncolytic Virotherapy[MESH]|Animals[MESH]|Clinical Trials as Topic[MESH]|Humans[MESH]|Immune System/*immunology[MESH]|Neoplasms/immunology[MESH]|Oncolytic Viruses/*immunology[MESH]|Receptors, Pattern Recognition/immunology[MESH] |