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lüll The pathophysiology, diagnosis, and treatment of constipation Muller-Lissner SDtsch Arztebl Int 2009[Jun]; 106 (25): 424-31; quiz 431-2BACKGROUND: Constipation is a common condition about which there are many widespread notions that have no basis in fact. The purpose of this article is to summarize current scientific knowledge on the subject. METHODS: Selective review of the literature. RESULTS: Diagnostic evaluation usually fails to reveal the cause of constipation. It is due to medications in some patients, while endocrine disorders are the cause in only a small minority. Abnormal defecation may be due to dysfunction of the pelvic floor. Most patients complain of abdominal fullness and of needing to strain to pass stool; low stool frequency is a rare symptom. The symptoms alone determine the indication for treatment. Constipation usually poses no threat to health. Some patients are helped by a diet rich in fiber, others by laxatives. A number of laxatives with different modes of action are available; all are safe and generally well tolerated. In some patients, dysfunctional defecation may be an indication for proctological surgery. CONCLUSIONS: The Rome criteria are useful for establishing a specific diagnosis of constipation. Most patients can be helped with laxatives and patient education.|Constipation/*diagnosis/physiopathology/*therapy[MESH]|Humans[MESH] |