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lüll Imaging of tumor angiogenesis: functional or targeted?Turkbey B; Kobayashi H; Ogawa M; Bernardo M; Choyke PLAJR Am J Roentgenol 2009[Aug]; 193 (2): 304-13OBJECTIVE: Angiogenesis--the growth of new vessels--is both a normal physiologic response and a critical step in many pathologic processes, particularly cancer. Imaging has long relied on the different enhancement characteristics of cancer compared with normal tissue; the information generated is often primarily morphologic and qualitative. However, more quantitative methods based on functional and targeted imaging have recently emerged. CONCLUSION: In this article, we review both functional and targeted imaging techniques for assessing tumor angiogenesis.|Animals[MESH]|Biomarkers, Tumor/*analysis[MESH]|Cell Line, Tumor[MESH]|Diagnostic Imaging/*methods[MESH]|Female[MESH]|Humans[MESH]|Image Enhancement/methods[MESH]|Lymphatic Metastasis/diagnosis[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Middle Aged[MESH]|Neoplasms/*blood supply[MESH]|Neovascularization, Pathologic/*diagnosis[MESH]|Positron-Emission Tomography/methods[MESH]|Tomography, X-Ray Computed/methods[MESH]|Ultrasonography/methods[MESH] |