Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Regeneration of the mammalian inner ear sensory epithelium Wei D; Yamoah ENCurr Opin Otolaryngol Head Neck Surg 2009[Oct]; 17 (5): 373-80PURPOSE OF REVIEW: This review will focus on 'self-repair' of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation RECENT FINDINGS: Self-repair refers to a favorable structural and functional outcome of damaged inner ear sensory epithelium. Our advanced ability of manipulating the fate of inner ear sensory cells makes in-situ proliferation a possible candidate of hearing restoration. A practical alternative of the unavoidable immune rejection is to introduce autologous cells. Ependymal cells, induced pluripotent stem cells, and olfactory neuroepithelial cells have been recognized as promising sources, which will spur ongoing efforts to evaluate these new cell sources for cell replacement therapy. SUMMARY: Further exploration of the innate advantages of in-situ proliferation and use of novel cell sources for autologous transplantation may serve as rehearsals for clinical trials in the near future.|Adult Stem Cells/physiology[MESH]|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/physiology[MESH]|Cell Differentiation[MESH]|Cell Proliferation[MESH]|Ear, Inner/physiology[MESH]|Epithelium/*physiology[MESH]|Genetic Therapy[MESH]|Hair Cells, Auditory, Inner/*physiology[MESH]|Hearing Loss, Sensorineural/physiopathology/surgery[MESH]|Homeostasis/physiology[MESH]|Humans[MESH]|Phenotype[MESH]|Regeneration/*physiology[MESH]|Transplantation, Autologous[MESH] |