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lüll Manipulation of T(H)17 responses in pulmonary immunity and disease through vaccination Sonnenberg GF; Weiner DBHum Vaccin 2009[Aug]; 5 (8): 510-9Since the discovery of a novel subset of CD4(+) T helper cells, T(H)17 cells have been implicated in a wide range of human diseases, including autoimmunity, allergic reactions and autoinflammatory diseases. Conversely, it has also been determined that T(H)17 cells are required to mount a protective immune response to a number of pathogens. It has therefore been of great interest to manipulate T(H)17 responses to either prevent disease or promote immunity. Vaccination is a particularly attractive approach for this manipulation. With a focus on the pulmonary mucosal environment, we herein review T(H)17 responses and potential methods for manipulation.|*Vaccination[MESH]|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|Cell Differentiation[MESH]|Gene Expression Regulation[MESH]|Host-Pathogen Interactions/immunology[MESH]|Humans[MESH]|Hypersensitivity/immunology[MESH]|Interleukin-17/biosynthesis/*immunology[MESH]|Lung Diseases/*immunology/*prevention & control[MESH]|Mice[MESH]|Pneumonia/immunology[MESH]|Respiratory Mucosa/immunology[MESH]|T-Lymphocyte Subsets/*immunology/metabolism[MESH]|T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH]|Vaccines, DNA/immunology[MESH] |