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lüll Adapalene 0 1% and benzoyl peroxide 2 5%: a novel combination for treatment of acne vulgaris Tan JKSkin Therapy Lett 2009[Jul]; 14 (6): 4-5Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (Epiduo, Galderma) and was approved by the US FDA in December 2008 for the treatment of acne. The superior efficacy of this combination was demonstrated in 2 large randomized controlled trials. This paper reviews the evidence for efficacy and tolerability of the combination of the retinoid adapalene 0.1% and BPO 2.5%, a once-daily gel formulation for the treatment of acne.|Acne Vulgaris/*drug therapy[MESH]|Adapalene[MESH]|Administration, Topical[MESH]|Benzoyl Peroxide/adverse effects/*therapeutic use[MESH]|Dermatologic Agents/adverse effects/*therapeutic use[MESH]|Drug Administration Schedule[MESH]|Drug Combinations[MESH]|Gels[MESH]|Humans[MESH]|Naphthalenes/adverse effects/*therapeutic use[MESH] |