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lüll Structure and function of HDL mimetics Navab M; Shechter I; Anantharamaiah GM; Reddy ST; Van Lenten BJ; Fogelman AMArterioscler Thromb Vasc Biol 2010[Feb]; 30 (2): 164-8HDL mimetics have been constructed from a number of peptides and proteins with varying structures, all of which bind lipids found in HDL. HDL mimetics containing a peptide or protein have been constructed with as few as 4 and as many as 243 amino acid residues. Some HDL mimetics have been constructed with lipid but without a peptide or protein component. Some HDL mimetics promote cholesterol efflux, some have been shown to have a remarkable ability to bind oxidized lipids compared to human apolipoprotein A-I (apoA-I). Many of these peptides have been shown to have antiinflammatory properties. Based on studies in a number of animal models and in early human clinical trials, HDL mimetics appear to have promise as diagnostic and therapeutic agents.|*Molecular Mimicry[MESH]|Administration, Oral[MESH]|Animals[MESH]|Anti-Inflammatory Agents/administration & dosage/chemistry/metabolism/*pharmacology[MESH]|Apolipoprotein A-I/metabolism[MESH]|Cardiovascular Diseases/*drug therapy/metabolism[MESH]|Cholesterol/metabolism[MESH]|Humans[MESH]|Hypolipidemic Agents/administration & dosage/chemistry/metabolism/*pharmacology[MESH]|Lipoproteins, HDL/chemistry/*metabolism[MESH]|Oxidation-Reduction[MESH]|Peptides/administration & dosage/chemistry/metabolism/*pharmacology[MESH]|Protein Binding[MESH]|Protein Conformation[MESH]|Structure-Activity Relationship[MESH] |