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Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas Bende RJ; van Maldegem F; van Noesel CJHaematologica 2009[Aug]; 94 (8): 1109-23Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.|Animals[MESH]|Autoimmune Diseases/genetics/*immunology/metabolism[MESH]|Cell Adhesion Molecules/metabolism[MESH]|Chemokines/metabolism[MESH]|Chronic Disease[MESH]|Humans[MESH]|Lymphoid Tissue/*immunology/metabolism[MESH]|Lymphoma, B-Cell/genetics/*immunology/metabolism[MESH]|Models, Biological[MESH]|Translocation, Genetic[MESH] |
