Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Cutting edge: SWI/SNF mediates antisense Igh transcription and locus-wide accessibility in B cell precursors Osipovich OA; Subrahmanyam R; Pierce S; Sen R; Oltz EMJ Immunol 2009[Aug]; 183 (3): 1509-13The stepwise process of Ag receptor gene assembly, termed V(D)J recombination, is coordinated during lymphocyte development by sweeping changes in chromatin that permit or deny access to a single recombinase enzyme. We now show that switching/sucrose nonfermenting (SWI/SNF) chromatin remodeling complexes are recruited to the Igh locus by an enhancer-dependent process and that these complexes are essential for generating recombinase accessibility throughout the locus. Depletion of SWI/SNF in pro-B cells also inhibits antisense transcription through all clusters of Igh gene segments, a pioneering process that has been implicated in the initial opening of chromatin. We conclude that SWI/SNF complexes play multiple roles in Igh gene assembly, ranging from initial locus activation to the spreading and maintenance of chromatin accessibility over large V(H), D(H), and J(H) domains.|*Chromatin Assembly and Disassembly[MESH]|Animals[MESH]|Chromosomal Proteins, Non-Histone/*genetics[MESH]|DNA, Antisense/genetics[MESH]|Enhancer Elements, Genetic[MESH]|Genes, Immunoglobulin Heavy Chain/*genetics[MESH]|Mice[MESH]|Precursor Cells, B-Lymphoid/*metabolism[MESH]|Transcription Factors/*genetics[MESH]|Transcription, Genetic[MESH]|VDJ Recombinases/metabolism[MESH] |