Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll A structural view on the mechanism of the ribosome-catalyzed peptide bond formation Simonovic M; Steitz TABiochim Biophys Acta 2009[Sep]; 1789 (9-10): 612-23The ribosome is a large ribonucleoprotein particle that translates genetic information encoded in mRNA into specific proteins. Its highly conserved active site, the peptidyl-transferase center (PTC), is located on the large (50S) ribosomal subunit and is comprised solely of rRNA, which makes the ribosome the only natural ribozyme with polymerase activity. The last decade witnessed a rapid accumulation of atomic-resolution structural data on both ribosomal subunits as well as on the entire ribosome. This has allowed studies on the mechanism of peptide bond formation at a level of detail that surpasses that for the classical protein enzymes. A current understanding of the mechanism of the ribosome-catalyzed peptide bond formation is the focus of this review. Implications on the mechanism of peptide release are discussed as well.|Amino Acids/chemistry[MESH]|Binding Sites[MESH]|Catalysis[MESH]|Crystallography, X-Ray/methods[MESH]|Guanosine Triphosphate/chemistry[MESH]|Kinetics[MESH]|Models, Chemical[MESH]|Molecular Conformation[MESH]|Nucleic Acid Conformation[MESH]|Peptides/*chemistry[MESH]|Peptidyl Transferases/chemistry[MESH]|RNA, Messenger/metabolism[MESH]|RNA, Transfer/chemistry[MESH]|Ribosomes/*chemistry[MESH]|Thermus/metabolism[MESH] |