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lüll CD40 and autoimmunity: the dark side of a great activator Peters AL; Stunz LL; Bishop GASemin Immunol 2009[Oct]; 21 (5): 293-300CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology. Diseases in which CD40 plays a pathogenic role include autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy.|Animals[MESH]|Autoimmunity/*immunology[MESH]|CD40 Antigens/*immunology[MESH]|CD40 Ligand/*immunology[MESH]|Humans[MESH]|Mice[MESH] |