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Pathogenesis of tendinopathies: inflammation or degeneration?Abate M; Silbernagel KG; Siljeholm C; Di Iorio A; De Amicis D; Salini V; Werner S; Paganelli RArthritis Res Ther 2009[]; 11 (3): 235The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies.|Animals[MESH]|Humans[MESH]|Inflammation Mediators/metabolism/*physiology[MESH]|Inflammation/immunology/metabolism/pathology[MESH]|Neovascularization, Pathologic/immunology/metabolism/pathology[MESH]|Tendinopathy/*immunology/metabolism/*pathology[MESH] |
