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lüll The role of insulin detemir in overweight type 2 diabetes management Demssie YN; Younis N; Soran HVasc Health Risk Manag 2009[]; 5 (3): 553-60The recent evidence-based shift towards an algorithm of early initiation and aggressive titration of insulin therapy in the management of type 2 diabetes requires the use of an effective insulin formulation that is both safe and acceptable to patients and physicians alike. The advent of the long-acting insulin analogues, insulin detemir and glargine, in the last decade has revolutionized insulin therapy in type 2 diabetes. Their unique pharmacokinetic and pharmacodynamic properties have offered tangible advantage over the conventional intermediate and long-acting insulin preparations in terms of improving glucose control as well as reducing risk of hypoglycemia and weight gain. This review focuses on the pharmacodynamic properties of the long-acting insulin analogue detemir, the outcome of studies on its relative efficacy and safety as well as its proposed place in the management of type 2 diabetes.|Blood Glucose/drug effects[MESH]|Diabetes Mellitus, Type 2/blood/complications/*drug therapy[MESH]|Glycated Hemoglobin/metabolism[MESH]|Humans[MESH]|Hypoglycemia/chemically induced[MESH]|Hypoglycemic Agents/adverse effects/pharmacokinetics/*therapeutic use[MESH]|Insulin Detemir[MESH]|Insulin, Long-Acting[MESH]|Insulin/adverse effects/*analogs & derivatives/pharmacokinetics/therapeutic use[MESH]|Overweight/blood/*complications[MESH]|Treatment Outcome[MESH]|Weight Gain/drug effects[MESH] |