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lüll Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa Khader SA; Gaffen SL; Kolls JKMucosal Immunol 2009[Sep]; 2 (5): 403-11T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.|Animals[MESH]|Cell Lineage[MESH]|Humans[MESH]|Immunity, Innate/*immunology[MESH]|Immunologic Deficiency Syndromes/immunology[MESH]|Immunotherapy[MESH]|Infections/*immunology[MESH]|Interleukins/metabolism[MESH]|Lymphocyte Cooperation/*immunology[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Models, Immunological[MESH]|Mucous Membrane/*immunology[MESH]|Receptors, Interleukin-17/deficiency/physiology[MESH]|Signal Transduction[MESH]|T-Lymphocyte Subsets/*immunology/metabolism[MESH]|T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH]|Tumor Necrosis Factor-alpha/metabolism[MESH] |