Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Toward unraveling the complexity of simple epithelial keratins in human disease Omary MB; Ku NO; Strnad P; Hanada SJ Clin Invest 2009[Jul]; 119 (7): 1794-805Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helped illuminate several keratin functions and served as important disease models. Insight into the contribution of SEKs to human disease has indicated that K8 and K18 are the major constituents of Mallory-Denk bodies, hepatic inclusions associated with several liver diseases, and are essential for inclusion formation. Furthermore, mutations in the genes encoding K8, K18, and K19 predispose individuals to a variety of liver diseases. Hence, as we discuss here, the SEK cytoskeleton is involved in the orchestration of several important cellular functions and contributes to the pathogenesis of human liver disease.|Animals[MESH]|Biomarkers, Tumor[MESH]|Humans[MESH]|Keratins/analysis/chemistry/genetics/*physiology[MESH]|Liver Diseases/etiology[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Mutation[MESH]|Neoplasm Metastasis[MESH]|Neoplasms, Glandular and Epithelial/diagnosis/therapy[MESH]|Proteins/physiology[MESH] |
