Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Proteasome inhibitors and cardiac cell growth Hedhli N; Depre CCardiovasc Res 2010[Jan]; 85 (2): 321-9Activation of the ubiquitin-proteasome system has been described in different models of cardiac hypertrophy. Cardiac cell growth in response to pressure or volume overload, as well as physiological adaptive hypertrophy, is accompanied by an increase in protein ubiquitination, proteasome subunit expression, and proteasome activity. Importantly, an inhibition of proteasome activity prevents and reverses cardiac hypertrophy and remodelling in vivo. The focus of this review is to provide an update about the mechanisms by which proteasome inhibitors affect cardiac cell growth in adaptive and maladaptive models of cardiac hypertrophy. In the first part, we summarize how the proteasome affects both proteolysis and protein synthesis in a context of cardiac cell growth. In the second part, we show how proteasome inhibition can prevent and reverse cardiac hypertrophy and remodelling in response to different conditions of overload.|*Proteasome Inhibitors[MESH]|Animals[MESH]|Cardiomegaly/drug therapy[MESH]|Cell Proliferation/drug effects[MESH]|Humans[MESH]|Myocytes, Cardiac/*drug effects[MESH]|Protease Inhibitors/*pharmacology[MESH]|Proteasome Endopeptidase Complex/physiology[MESH]|Protein Biosynthesis[MESH]|Proteins/metabolism[MESH]|Ubiquitin/*metabolism[MESH]|Ventricular Remodeling/drug effects[MESH] |