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lüll Structure and signalling in the IL-17 receptor family Gaffen SLNat Rev Immunol 2009[Aug]; 9 (8): 556-67Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (T(H)17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the founding members of a newly described family of cytokines and receptors that have unique structural features which distinguish them from other cytokine families. Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL-17R family to mediate downstream events.|Animals[MESH]|Autoimmune Diseases/immunology/metabolism[MESH]|Cytokines/immunology/*metabolism[MESH]|Humans[MESH]|Inflammation/immunology/metabolism[MESH]|Interleukin-17/immunology/*metabolism[MESH]|Receptors, Interleukin-17/immunology/*metabolism[MESH]|Signal Transduction/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH] |