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lüll Understanding melanoma signaling networks as the basis for molecular targeted therapy Smalley KSJ Invest Dermatol 2010[Jan]; 130 (1): 28-37Despite years of research, there has been little improvement in survival for patients with disseminated melanoma. Recent work has identified mutations in BRAF and NRAS, leading to constitutive mitogen-activated protein kinase (MAPK) pathway as well as constitutive activity in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway, as being critical events in melanoma growth and progression. In the current review, we discuss how these complex mutational and signaling profiles can be understood using a network biology approach, and suggest how an understanding of the key signaling nodes involved in progression and survival will lead to improvements in melanoma therapy.|Enzyme Inhibitors/*therapeutic use[MESH]|Humans[MESH]|Melanoma/*drug therapy/metabolism[MESH]|Signal Transduction/*drug effects/physiology[MESH]|Skin Neoplasms/*drug therapy/metabolism[MESH] |