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An update on nuclear calcium signalling Bootman MD; Fearnley C; Smyrnias I; MacDonald F; Roderick HLJ Cell Sci 2009[Jul]; 122 (Pt 14): 2337-50Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca2+ signalling and discuss what is known about the origin and physiological significance of nuclear Ca2+ transients. In particular, we focus on the idea that the nucleus has an autonomous Ca2+ signalling system that can generate its own Ca2+ transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm.|*Calcium Signaling[MESH]|Animals[MESH]|Calcium Channels/metabolism[MESH]|Calcium/*metabolism[MESH]|Cell Nucleus/*metabolism[MESH]|Cytosol/metabolism[MESH]|Humans[MESH]|Kinetics[MESH]|Nuclear Pore/metabolism[MESH]|Transcription, Genetic[MESH] |
