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CTCF: master weaver of the genome Phillips JE; Corces VGCell 2009[Jun]; 137 (7): 1194-211CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.|*Gene Expression Regulation[MESH]|*Genome[MESH]|Animals[MESH]|CCCTC-Binding Factor[MESH]|Chromatin/*metabolism[MESH]|Humans[MESH]|Repressor Proteins/*metabolism[MESH] |
