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lüll Autophagy in neurodegeneration: two sides of the same coin Lee JABMB Rep 2009[Jun]; 42 (6): 324-30Autophagy is a bulk lysosomal degradation process important in development, differentiation and cellular homeostasis in multiple organs. Interestingly, neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology and active protein trafficking. A growing body of evidence now suggests that alteration or dysfunction of autophagy causes accumulation of abnormal proteins and/or damaged organelles, thereby leading to neurodegenerative disease. Although autophagy generally prevents neuronal cell death, it plays a protective or detrimental role in neurodegenerative disease depending on the environment. In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases.|Autophagy/*physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Nerve Degeneration/*etiology/pathology[MESH]|Neurodegenerative Diseases/etiology/pathology[MESH]|Signal Transduction/physiology[MESH] |