Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions Yang B; Kumar SCell Death Differ 2010[Jan]; 17 (1): 68-77The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member consisting of a C2 domain, 2-4 WW domains, and a HECT-type ligase domain. Of the nine mammalian members of this family, Nedd4 and its close relative, Nedd4-2, represent the ancestral ligases with strong similarity to the yeast, Rsp5. In Saccharomyces cerevisiae Rsp5 has a key role in regulating the trafficking, sorting, and degradation of a large number of proteins in multiple cellular compartments. However, in mammals the Nedd4 family members, including Nedd4 and Nedd4-2, appear to have distinct functions, thereby suggesting that these E3s target specific proteins for ubiquitylation. In this article we focus on the biology and emerging functions of Nedd4 and Nedd4-2, and review recent in vivo studies on these E3s.|14-3-3 Proteins/metabolism[MESH]|Endosomal Sorting Complexes Required for Transport/classification/metabolism/*physiology[MESH]|Epithelial Sodium Channels/metabolism[MESH]|Immediate-Early Proteins/metabolism[MESH]|Nedd4 Ubiquitin Protein Ligases[MESH]|Neuromuscular Junction/physiology[MESH]|PTEN Phosphohydrolase/metabolism[MESH]|Protein Serine-Threonine Kinases/metabolism[MESH]|Saccharomyces cerevisiae Proteins/metabolism/physiology[MESH]|Sodium Channels/metabolism[MESH]|Ubiquitin-Protein Ligase Complexes/metabolism/physiology[MESH]|Ubiquitin-Protein Ligases/classification/metabolism/*physiology[MESH]|Ubiquitination[MESH] |