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Peroxisome proliferator-activated receptor gamma agonists in kidney disease--future promise, present fears Mao Z; Ong ACNephron Clin Pract 2009[]; 112 (4): c230-41The peroxisome proliferator-activated receptor superfamily (PPARs) comprises a class of nuclear receptors with significant effects in regulating multiple cellular pathways. Much research and clinical interest has surrounded the PPAR-gamma isoform because of its key role in the transcriptional regulation of metabolic pathways and the efficacy of thiazolidinediones, the most clinically used PPAR-gamma agonist, in the management of type 2 diabetes mellitus. In this review, we discuss the pathogenic role of PPAR-gamma in experimental models of kidney disease, clinical trials of thiazolidinediones in diabetic and non-diabetic kidney disease, recent safety concerns surrounding PPAR-gamma agonists and reflect on their potential use in 'orphan' kidney diseases.|*Forecasting[MESH]|Humans[MESH]|Kidney Diseases/*drug therapy/*metabolism[MESH]|Kidney/drug effects/*metabolism[MESH]|Nephrology/trends[MESH]|PPAR gamma/*agonists/*metabolism[MESH]|Thiazolidinediones/*administration & dosage[MESH] |
