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lüll Role of specific microRNAs for endothelial function and angiogenesis Wu F; Yang Z; Li GBiochem Biophys Res Commun 2009[Sep]; 386 (4): 549-53Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.|*Neovascularization, Physiologic/genetics[MESH]|Animals[MESH]|Endothelium, Vascular/*metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Mice[MESH]|MicroRNAs/metabolism/*physiology[MESH]|Ribonuclease III/genetics/*physiology[MESH] |