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CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract Beswick EJ; Reyes VEWorld J Gastroenterol 2009[Jun]; 15 (23): 2855-61CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.|Antigen Presentation/*immunology[MESH]|Antigens, Differentiation, B-Lymphocyte/*immunology[MESH]|Gastrointestinal Neoplasms/*immunology[MESH]|Helicobacter Infections/immunology[MESH]|Helicobacter pylori/immunology[MESH]|Histocompatibility Antigens Class II/*immunology[MESH]|Humans[MESH]|Inflammation/*immunology[MESH]|Interleukin-8/immunology[MESH]|Macrophage Migration-Inhibitory Factors/immunology[MESH]|Protein Isoforms/immunology[MESH]|Signal Transduction/immunology[MESH] |
