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lüll Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus Naesens R; Ronsyn M; Druwe P; Denis O; Ieven M; Jeurissen AJ Med Microbiol 2009[Sep]; 58 (Pt 9): 1247-1251We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA.|*Methicillin-Resistant Staphylococcus aureus[MESH]|Adult[MESH]|Anti-Bacterial Agents/therapeutic use[MESH]|Bacteremia[MESH]|Brain Abscess/drug therapy/microbiology[MESH]|Cavernous Sinus Thrombosis/drug therapy/*microbiology/surgery[MESH]|Central Nervous System Bacterial Infections/drug therapy/*microbiology/surgery[MESH]|Community-Acquired Infections/drug therapy/*microbiology/surgery[MESH]|Fatal Outcome[MESH]|Humans[MESH]|Male[MESH]|Meningitis, Bacterial/drug therapy/microbiology[MESH]|Staphylococcal Infections/drug therapy/*microbiology/surgery[MESH] |