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Pathogenesis of Henoch-Schonlein purpura nephritis Lau KK; Suzuki H; Novak J; Wyatt RJPediatr Nephrol 2010[Jan]; 25 (1): 19-26The severity of renal involvement is the major factor determining the long-term outcome of children with Henoch-Schonlein purpura (HSP) nephritis (HSPN). Approximately 40% children with HSP develop nephritis, usually within 4 to 6 weeks after the initial onset of the typical purpuric rashes. Although the pathogenetic mechanisms are still not fully delineated, several studies suggest that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, leading to the formation of the circulating immune complexes and their mesangial deposition that induce renal injury in HSPN.|Antigen-Antibody Complex/blood[MESH]|Child[MESH]|Galactose/deficiency/immunology[MESH]|Glomerular Mesangium/immunology/metabolism[MESH]|Glomerulonephritis, IGA/genetics/immunology/*metabolism[MESH]|Humans[MESH]|IgA Vasculitis/genetics/immunology/*metabolism[MESH]|Immune Complex Diseases[MESH]|Immunoglobulin A/genetics/immunology/*metabolism[MESH] |
