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lüll Hodgkin lymphoma: an update on its biology with new insights into classification Mani H; Jaffe ESClin Lymphoma Myeloma 2009[Jun]; 9 (3): 206-16In the past few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma (HL). In standard texts, HL is classified as 2 distinct entities, namely nodular lymphocyte-predominant HL and classical HL (CHL). However, recent evidence suggests that CHL is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes might be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review.|Adolescent[MESH]|Adult[MESH]|Apoptosis[MESH]|Cytokines/metabolism[MESH]|Female[MESH]|Genetic Predisposition to Disease[MESH]|HIV Infections/metabolism[MESH]|Herpesvirus 4, Human/metabolism[MESH]|Hodgkin Disease/*classification/*diagnosis/genetics[MESH]|Humans[MESH]|Immunophenotyping[MESH]|Lymphocytes/metabolism[MESH]|Lymphoma, B-Cell/metabolism[MESH]|Male[MESH]|Social Class[MESH] |