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lüll Therapeutic potential of "rexinoids" in cancer prevention and treatment Tanaka T; De Luca LMCancer Res 2009[Jun]; 69 (12): 4945-7Retinoid X receptor (RXR) is a combinatorial partner for one third of the 48 human nuclear receptor superfamily members and acts as a master coordinator of nuclear receptor signaling pathways involved in the control of cell growth and differentiation. Thus, ligand-dependent simultaneous activation of multiple pathways is an attractive strategy for molecular-targeted therapy of neoplastic disease. However, clinical trials in RXR-targeted molecular therapy with the RXR ligand (rexinoid) have yielded disappointing outcomes. In this review, we discuss a possible mechanism underlying the loss of sensitivity to rexinoid therapy.|Antineoplastic Agents/pharmacology/*therapeutic use[MESH]|Base Sequence[MESH]|Humans[MESH]|Ligands[MESH]|Neoplasms/*drug therapy/*prevention & control[MESH]|Retinoid X Receptors/*drug effects/metabolism[MESH] |