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lüll Eribulin: rediscovering tubulin as an anticancer target Jimeno AClin Cancer Res 2009[Jun]; 15 (12): 3903-5Eribulin mesylate (E7389) is a synthetic analog of the marine macrolide halichondrin B, which acts as a novel microtubule modulator with a distinct mechanism of action. Two eribulin mesylate phase 1 studies exploring weekly and 3-weekly schedules are reported in this issue. These trials show linear pharmacokinetics, a toxicity profile consisting in neutropenia and fatigue, and early hints of antitumor activity. In this commentary we give a brief historical perspective of the halichondrins and put into context eribulin mesylate as a novel tubulin modulator.|Antineoplastic Agents/administration & dosage/adverse effects/*therapeutic use[MESH]|Clinical Trials, Phase I as Topic[MESH]|Furans/administration & dosage/adverse effects/*therapeutic use[MESH]|Humans[MESH]|Ketones/administration & dosage/adverse effects/*therapeutic use[MESH]|Neoplasms/*drug therapy/metabolism[MESH]|Tubulin Modulators/administration & dosage/adverse effects/*therapeutic use[MESH]|Tubulin/*metabolism[MESH] |