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lüll Metformin for obesity in children and adolescents: a systematic review Park MH; Kinra S; Ward KJ; White B; Viner RMDiabetes Care 2009[Sep]; 32 (9): 1743-5OBJECTIVE: To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes. RESEARCH DESIGN AND METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subjects age < or =19 years without diabetes were included. Our primary outcomes of interest include changes in BMI and measures of insulin sensitivity. RESULTS: Five trials met inclusion criteria (n = 320 individuals). Compared with placebo, metformin reduced BMI by 1.42 kg/m(2) (95% CI 0.83-2.02) and homeostasis model assessment insulin of resistance (HOMA-IR) score by 2.01 (95% CI 0.75-3.26). CONCLUSIONS: Metformin appears to be moderately efficacious in reducing BMI and insulin resistance in hyperinsulinemic obese children and adolescents in the short term. Larger, longer-term studies in different populations are needed to establish its role in the treatment of overweight children.|Adolescent[MESH]|Body Mass Index[MESH]|Cardiovascular Diseases/prevention & control[MESH]|Child[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Metformin/*therapeutic use[MESH]|Obesity/*drug therapy[MESH]|Randomized Controlled Trials as Topic[MESH] |