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The NLRP3 inflammasome: a sensor of immune danger signals Cassel SL; Joly S; Sutterwala FSSemin Immunol 2009[Aug]; 21 (4): 194-8The innate immune system senses danger signals via evolutionary conserved receptors. The nucleotide-binding domain leucine-rich repeat containing receptor (NLR) family is a group of intracellular receptors that drive a wide variety of inflammatory responses. A number of the NLR family members can form inflammasomes, which are multiprotein complexes that can activate caspase-1 and ultimately lead to the processing and secretion of interleukin (IL)-1beta, IL-18 and IL-33. One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review.|*Signal Transduction[MESH]|Animals[MESH]|Biological Transport[MESH]|Humans[MESH]|Inflammation/*immunology/metabolism[MESH]|Receptors, G-Protein-Coupled/*immunology/metabolism[MESH]|Vaccines/immunology[MESH] |
