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lüll Aurora-A and hBora join the game of Polo Macurek L; Lindqvist A; Medema RHCancer Res 2009[Jun]; 69 (11): 4555-8Overactivation of both Polo-like kinase-1 (Plk1) and Aurora-A is linked to cancer development, and small-molecule inhibitors that target these kinases are currently tested as anticancer drugs. Here, we discuss recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. Several recent findings have led to a better appreciation of how the activities of these distinct mitotic kinases are intertwined. Such insight is important for the expected utility of small-molecule inhibitors targeting Plk1 or Aurora-A, and it might help us to improve their application.|Animals[MESH]|Aurora Kinases[MESH]|Cell Cycle Proteins/*metabolism/*physiology[MESH]|Enzyme Activation/physiology[MESH]|G2 Phase/physiology[MESH]|Humans[MESH]|Mitosis/physiology[MESH]|Models, Biological[MESH]|Polo-Like Kinase 1[MESH]|Protein Processing, Post-Translational/physiology[MESH]|Protein Serine-Threonine Kinases/*metabolism/*physiology[MESH]|Proto-Oncogene Proteins/*metabolism[MESH]|Signal Transduction/physiology[MESH] |