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Replication licensing and the DNA damage checkpoint Cook JGFront Biosci (Landmark Ed) 2009[Jun]; 14 (13): 5013-30Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings suggest that checkpoints and replication are more intimately associated than previously appreciated, even in the absence of exogenous DNA damage. This review summarizes some of these developments.|*DNA Damage[MESH]|Animals[MESH]|Cell Cycle Proteins/metabolism[MESH]|Cell Cycle/genetics/*physiology[MESH]|Checkpoint Kinase 1[MESH]|Cyclin-Dependent Kinases/metabolism[MESH]|DNA Replication/genetics/*physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Origin Recognition Complex/metabolism[MESH]|Phosphorylation[MESH]|Protein Kinases/metabolism[MESH]|Signal Transduction[MESH]|Transcription Factors/metabolism[MESH]|Ubiquitination[MESH] |
