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Wegener s granulomatosis: a model of auto-antibodies in mucosal autoimmunity Kelley JM; Edberg JC; Kimberly RPClin Immunol 2010[Feb]; 134 (2): 104-12Wegener's granulomatosis (WG) is an autoimmune condition marked by vasculitis of small and medium sized vessels particularly affecting the upper respiratory tract and kidneys. There is a strong mucosal component similar to other autoimmune conditions such as systemic lupus erythematosus and Behcet's disease. While the pathogenesis of WG is not completely known, auto-antibodies such as IgG ANCAs have been implicated in endovascular damage and modulation of neutrophil/monocyte responses by Fc receptor (FcR) signaling. Due to the substantial mucosal involvement in WG (oral, nasal, and upper respiratory tract involvement), it is probable that IgA antibodies (perhaps IgA ANCAs) play a role in disease. Given discrepancies in associating ANCA levels with disease activity, future work should determine if IgA ANCAs are present in WG patients and examine the biology underlying the ANCAs' signaling partners--the FcRs.|*Autoimmunity[MESH]|Antibodies, Antineutrophil Cytoplasmic/*immunology[MESH]|Autoantibodies/*immunology[MESH]|Granulomatosis with Polyangiitis/*immunology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Mucous Membrane/*immunology[MESH]|Receptors, Fc/immunology[MESH] |
