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Coronary microvascular resistance: methods for its quantification in humans Knaapen P; Camici PG; Marques KM; Nijveldt R; Bax JJ; Westerhof N; Gotte MJ; Jerosch-Herold M; Schelbert HR; Lammertsma AA; van Rossum ACBasic Res Cardiol 2009[Sep]; 104 (5): 485-98Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses.|*Coronary Circulation[MESH]|*Heart Function Tests/methods[MESH]|*Microcirculation[MESH]|*Vascular Resistance[MESH]|Cardiac Catheterization[MESH]|Coronary Angiography[MESH]|Coronary Artery Disease/*diagnosis/physiopathology[MESH]|Coronary Vessels/*physiopathology[MESH]|Echocardiography, Doppler[MESH]|Fractional Flow Reserve, Myocardial[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Positron-Emission Tomography[MESH]|Predictive Value of Tests[MESH]|Thermodilution[MESH] |
