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Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis Wajchenberg BL; Nery M; Cunha MR; Silva MEArq Bras Endocrinol Metabol 2009[Mar]; 53 (2): 145-50The authors analyze insulin resistance, the metabolic syndrome and endothelial dysfunction as consequence of a common antecedent, a low grade inflammation, indicating that in obesity there is a chronically activated inflammatory state of the adipose tissue. Furthermore, the inflammatory signaling is discussed according to the adipose tissue depot, visceral or subcutaneous.|Adipokines/metabolism[MESH]|Adipose Tissue/metabolism/*physiology[MESH]|Animals[MESH]|Atherosclerosis/etiology/*physiopathology[MESH]|Endothelium, Vascular/metabolism[MESH]|Humans[MESH]|Inflammation Mediators/metabolism[MESH]|Insulin Resistance/*physiology[MESH]|Intra-Abdominal Fat/metabolism[MESH]|Metabolic Syndrome/etiology/*physiopathology[MESH]|Obesity/complications/metabolism/*physiopathology[MESH]|Panniculitis/metabolism/*physiopathology[MESH]|Subcutaneous Fat/metabolism[MESH] |
