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lüll Control of regulatory T cell lineage commitment and maintenance Josefowicz SZ; Rudensky AImmunity 2009[May]; 30 (5): 616-25Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.|*Cell Lineage[MESH]|Animals[MESH]|Cell Differentiation/*immunology[MESH]|Cytokines/immunology/metabolism[MESH]|Forkhead Transcription Factors/genetics/immunology/metabolism[MESH]|Humans[MESH]|Protein Kinases/immunology/metabolism[MESH]|Receptors, Antigen, T-Cell/*immunology/metabolism[MESH]|T-Lymphocyte Subsets/*immunology/metabolism[MESH]|T-Lymphocytes, Regulatory/*immunology/metabolism[MESH]|Thymus Gland/immunology[MESH] |